The Block Relevance (BR) analysis to aid medicinal chemists to determine and interpret lipophilicity
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The Block Relevance (BR) analysis supports the dominating effect of solutes hydrogen bond acidity on ΔlogP(oct-tol).
The role of hydrogen bond acidity, i.e., the ability of chemicals to act as hydrogen bond donors (HBD), is a crucial element in pharmaceutical sciences and medicinal chemistry. It has been shown that the difference between logP values (ΔlogP) obtained in two different biphasic systems is informative of the solutes HBD properties and thus useful in the prediction of drugs human fate. In this stu...
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تاریخ انتشار 2014